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Article

MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors.

Journal of neuro-oncology - 1 May 2012

Mellai Marta, Monzeglio Oriana, Piazzi Angela, Caldera Valentina, Annovazzi Laura, Cassoni Paola, Valente Guido, Cordera Susanna, Mocellini Cristina, Schiffer Davide

Abstract excerpt

MGMT (O⁶-methylguanine-DNA methyltransferase) promoter hypermethylation is a helpful prognostic marker for chemotherapy of gliomas, although with some controversy for low-grade tumors. The objective of this study was to retrospectively investigate MGMT promoter hypermethylation status for a series of 350 human brain tumors, including 275 gliomas of different malignancy grade, 21 glioblastoma multiforme (GBM) cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22287028
DOI: 10.1007/s11060-011-0787-y

Genes

MGMT
IDH1
IDH2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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