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Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation.

Genes and immunity - 1 Sept 2016

Gianfrancesco M A, Balzer L, Taylor K E, Trupin L, Nititham J, Seldin M F, Singer A W, Criswell L A, Barcellos L F

Abstract excerpt

Systemic lupus erythematous (SLE) is a chronic autoimmune disease associated with genetic and environmental risk factors. However, the extent to which genetic risk is causally associated with disease activity is unknown. We utilized longitudinal-targeted maximum likelihood estimation to estimate the causal association between a genetic risk score (GRS) comprising 41 established SLE variants and clinically...

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Identifiers

PMID: 27467283
DOI: 10.1038/gene.2016.33
PMCID: PMC5008986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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