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Article

Integrated analysis of polygenic and environmental risk scores for late-onset systemic lupus erythematosus.

Journal of autoimmunity - 1 Jun 2025

Hocaoǧlu Mehmet, Sawalha Amr H

Abstract excerpt

OBJECTIVE: Polygenic risk scores (PRS) have been constructed to summarize genetic risk but there is limited research on environment-wide analysis of risk factors for systemic lupus erythematosus (SLE). In this study, we performed an environment-wide association study to construct an environmental risk score (ERS) for SLE and compare the risk conferred by ERS and PRS. METHODS: A total of 335 incident SLE cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40440800
DOI: 10.1016/j.jaut.2025.103441
PMCID: PMC13215970

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