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Article

Identified genetic locus for longitudinal disease activity in adults with systemic lupus erythematosus.

Rheumatology (Oxford, England) - 1 Jul 2025

Misztal Melissa C, Liao Fangming, Gold Nick, Cao Jingjing, Gladman Dafna D, Touma Zahi, Wither Joan, Cook Richard, Urowitz Murray, Hiraki Linda T

Abstract excerpt

OBJECTIVES: Genetics significantly impacts systemic lupus erytematosus (SLE) risk, disease manifestations, and damage. Our aim was to identify genetic risk loci for disease activity burden over time. METHODS: We included participants from a tertiary care lupus clinic. Participants met ACR and/or SLICC classification criteria for SLE, were genotyped on one of three arrays and had ≥3 measures of disease activity...

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PMID: 40036173
DOI: 10.1093/rheumatology/keaf093

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ACR

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