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Article

Genetics of longitudinal kidney function in children and adults with systemic lupus erythematosus.

Rheumatology (Oxford, England) - 2 Nov 2023

Tang Thai-Son, Liao Fangming, Webber Declan, Gold Nicholas, Cao Jingjing, Dominguez Daniela, Gladman Dafna, Knight Andrea, Levy Deborah M, Ng Lawrence, Paterson Andrew D, Touma Zahi, Urowitz Murray B, Wither Joan, Silverman Earl D, Pullenayegum Eleanor M, Hiraki Linda T

Abstract excerpt

OBJECTIVES: Genome-wide association studies (GWAS) have identified loci associated with estimated glomerular filtration rate (eGFR). Few LN risk loci have been identified to date. We tested the association of SLE and eGFR polygenic risk scores (PRS) with repeated eGFR measures from children and adults with SLE. METHODS: Patients from two tertiary care lupus clinics that met ≥4 ACR and/or SLICC criteria for SLE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36916720
DOI: 10.1093/rheumatology/kead119
PMCID: PMC10629779

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