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Article

Polygenic Risk and Linked Metabolic Profile in Systemic Lupus Erythematosus: Cross-Sectional Insights.

Genes - 1 Jan 2026

Higuera-Gómez Andrea, Martínez-Urbistondo María, Cuevas-Sierra Amanda, de Cuevillas Begoña, De la Cruz-Mosso Ulises, Nicoletti Carolina F, da Mota Jhulia C N L, Mellor-Pita Susana, Alonso-Bernáldez Marta, Vizmanos Barbara, Martínez J Alfredo

Abstract excerpt

Background/Objectives: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a multifactorial origin involving genetic, epigenetic, and environmental determinants as well as some risk factors. Genetic predisposition has been quantified through polygenic risk scores (PRS), which integrate the cumulative effect of multiple single nucleotide variants (SNVs) associated with disease risk. Despite...

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Identifiers

PMID: 41595473
DOI: 10.3390/genes17010053
PMCID: PMC12841000

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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