Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes.

doi:10.1038/s41379-022-01074-y

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Article

Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2022

Sakhdari Ali, Class Caleb, Montalban-Bravo Guillermo, Sasaki Koji, Bueso-Ramos Carlos E, Patel Keyur P, Routbort Mark J, Loghavi Sanam, Ok Chi Young, Quesada Andres, Khoury Joseph D, Konoplev Sergej N, Kantarjian Hagop P, Garcia-Manero Guillermo, Medeiros L Jeffrey, Kanagal-Shamanna Rashmi

Abstract excerpt

EZH2 coding mutation (EZH2MUT), resulting in loss-of-function, is an independent predictor of overall survival in MDS. EZH2 function can be altered by other mechanisms including copy number changes, and mutations in other genes and non-coding regions of EZH2. Assessment of EZH2 protein can identify alterations of EZH2 function missed by mutation assessment alone. Precise evaluation of EZH2 function and...

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PMID: 35504958
DOI: 10.1038/s41379-022-01074-y
PMCID: PMC13105204

Genes

ASXL1
RUNX1
TET2

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