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Article

Knee Osteoarthritis Progression Is Delayed in Silent Information Regulator 2 Ortholog 1 Knock-in Mice.

International journal of molecular sciences - 1 Oct 2021

Yamamoto Tetsuya, Miyaji Nobuaki, Kataoka Kiminari, Nishida Kyohei, Nagai Kanto, Kanzaki Noriyuki, Hoshino Yuichi, Kuroda Ryosuke, Matsushita Takehiko

Abstract excerpt

Overexpression of silent information regulator 2 ortholog 1 (SIRT1) is associated with beneficial roles in aging-related diseases; however, the effects of SIRT1 overexpression on osteoarthritis (OA) progression have not yet been studied. The aim of this study was to investigate OA progression in SIRT1-KI mice using a mouse OA model. OA was induced via destabilization of the medial meniscus using 12-week-old...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34639026
DOI: 10.3390/ijms221910685
PMCID: PMC8508837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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