Article

Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor- <i>α</i>

2023-02-03

Abstract excerpt

<h4>Background/Objective</h4> Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development and its ligand transforming growth factor- α (TGl· α ) is upregulated in OA. In contrast, Mitogen-inducible gene 6 (Mig6) is a negative regulator of EGFR, and our st...

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Literature Corpus work: 446e9c5b-d890-536a-8c2f-216f1d7d4f09
DOI: 10.1101/2023.01.31.526523

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