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Article

Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin.

The Journal of infectious diseases - 1 Oct 2016

Guggisberg Ann M, Sundararaman Sesh A, Lanaspa Miguel, Moraleda Cinta, González Raquel, Mayor Alfredo, Cisteró Pau, Hutchinson David, Kremsner Peter G, Hahn Beatrice H, Bassat Quique, Odom Audrey R

Abstract excerpt

Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in Mozambican children with uncomplicated Plasmodium falciparum malaria 7 days after combination treatment with fosmidomycin-clindamycin. However, 28-day cure rates were low (45.9%), owing to parasite recrudescence. We sought to identify any genetic changes...

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Identifiers

PMID: 27443612
DOI: 10.1093/infdis/jiw304
PMCID: PMC5021231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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