Article
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Science (New York, N.Y.) - 12 Jan 2018
Cowell Annie N, Istvan Eva S, Lukens Amanda K, Gomez-Lorenzo Maria G, Vanaerschot Manu, Sakata-Kato Tomoyo, Flannery Erika L, Magistrado Pamela, Owen Edward, Abraham Matthew, LaMonte Gregory, Painter Heather J, Williams Roy M, Franco Virginia, Linares Maria, Arriaga Ignacio, Bopp Selina, Corey Victoria C, Gnädig Nina F, Coburn-Flynn Olivia, Reimer Christin, Gupta Purva, Murithi James M, Moura Pedro A, Fuchs Olivia, Sasaki Erika, Kim Sang W, Teng Christine H, Wang Lawrence T, Akidil Aslı, Adjalley Sophie, Willis Paul A, Siegel Dionicio, Tanaseichuk Olga, Zhong Yang, Zhou Yingyao, Llinás Manuel, Ottilie Sabine, Gamo Francisco-Javier, Lee Marcus C S, Goldberg Daniel E, Fidock David A, Wirth Dyann F, Winzeler Elizabeth A
Abstract excerpt
Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes. We performed a genome analysis of 262 Plasmodium falciparum parasites resistant to 37 diverse compounds. We found 159 gene amplifications and 148 nonsynonymous changes in 83 genes associated with drug-resistance acquisition, where gene amplifications...
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