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Article

Comparison of techniques and markers to distinguish Plasmodium falciparum recrudescence from new infection in Rwanda.

Scientific reports - 10 Jun 2026

Cantoreggi Sara L, Golumbeanu Monica, Zwyer Michaela, Uwimana Aline, Niyonzima Jean Damascene, Mbituyumuremyi Aimable, Lucchi Naomi W, Plucinski Mateusz M, Nsanzabana Christian

Abstract excerpt

Accurate estimation of antimalarial drug efficacy against P. falciparum requires PCR correction to distinguish recrudescence from new infection in recurrent infections. Here, we compared two different genotyping techniques and different decision algorithms used for PCR correction using samples collected in a Therapeutic Efficacy Study (TES) conducted in Rwanda in 2018. We first optimized an assay to genotype four...

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Identifiers

PMID: 42270857
DOI: 10.1038/s41598-026-57063-7
PMCID: PMC13500532

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TES

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