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Article

Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2024

Tang Soon Yew, Lordan Ronan, Meng Hu, Auerbach Benjamin J, Hennessy Elizabeth J, Sengupta Arjun, Das Ujjalkumar S, Joshi Robin, Marcos-Contreras Oscar A, McConnell Ryan, Grant Gregory R, Ricciotti Emanuela, Muzykantov Vladimir R, Grosser Tilo, Weiljie Aalim M, FitzGerald Garret A

Abstract excerpt

BACKGROUND: Low-dose aspirin is widely used for the secondary prevention of cardiovascular disease. The beneficial effects of low-dose aspirin are attributable to its inhibition of platelet Cox (cyclooxygenase)-1-derived thromboxane A2. Until recently, the use of the Pf4 (platelet factor 4) Cre has been the only genetic approach to generating megakaryocyte/platelet ablation of Cox-1 in mice. However, Pf4-ΔCre...

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Identifiers

PMID: 38660804
DOI: 10.1161/ATVBAHA.123.320295
PMCID: PMC11138953

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