Article
Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2017
Li Hongyan, Feng Bingjian, Miron Alexander, Chen Xiaoqing, Beesley Jonathan, Bimeh Emmanuella, Barrowdale Daniel, John Esther M, Daly Mary B, Andrulis Irene L, Buys Saundra S, Kraft Peter, Thorne Heather, Chenevix-Trench Georgia, Southey Melissa C, Antoniou Antonis C, James Paul A, Terry Mary Beth, Phillips Kelly-Anne, Hopper John L, Mitchell Gillian, Goldgar David E
Abstract excerpt
PURPOSE: This study examined the utility of sets of single-nucleotide polymorphisms (SNPs) in familial but non-BRCA-associated breast cancer (BC). METHODS: We derived a polygenic risk score (PRS) based on 24 known BC risk SNPs for 4,365 women from the Breast Cancer Family Registry and Kathleen Cuningham Consortium Foundation for Research into Familial Breast Cancer familial BC cohorts. We compared scores for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.