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Article

Detection of gene-environment interaction in pedigree data using genome-wide genotypes.

European journal of human genetics : EJHG - 1 Dec 2016

Nivard Michel G, Middeldorp Christel M, Lubke Gitta, Hottenga Jouke-Jan, Abdellaoui Abdel, Boomsma Dorret I, Dolan Conor V

Abstract excerpt

Heritability may be estimated using phenotypic data collected in relatives or in distantly related individuals using genome-wide single nucleotide polymorphism (SNP) data. We combined these approaches by re-parameterizing the model proposed by Zaitlen et al and extended this model to include moderation of (total and SNP-based) genetic and environmental variance components by a measured moderator. By means of data...

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Identifiers

PMID: 27436263
DOI: 10.1038/ejhg.2016.88
PMCID: PMC5117937

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