Article
Genetic sensitivity analysis: adjusting for genetic confounding in epidemiological associations
2019-03-30
Abstract excerpt
Associations between exposures and outcomes reported in epidemiological studies are typically unadjusted for genetic confounding. We propose a two-stage approach for estimating the degree to which such observed associations can be explained by genetic confounding. First, we assess attenuation of exposure effects in regressions controlling for increasingly powerful polygenic scores. Second, we use structural equati...
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Identifiers and source
- Literature Corpus work
- 9723cab2-45d7-58e8-a5b6-464bd14dccb3
- DOI
- 10.1101/592352