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Article

Gene-gene and gene-environment interactions in meta-analysis of genetic association studies.

PloS one - 1 Jan 2015

Lin Chin, Chu Chi-Ming, Lin John, Yang Hsin-Yi, Su Sui-Lung

Abstract excerpt

Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases. Some researchers have proposed that the "missing heritability" may be attributable to gene-gene and gene-environment interactions. Because there are billions of potential interaction combinations, the statistical power of a...

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Identifiers

PMID: 25923960
DOI: 10.1371/journal.pone.0124967
PMCID: PMC4414456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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