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Article

T300A variant of autophagy ATG16L1 gene is associated with decreased antigen sampling and processing by dendritic cells in pediatric Crohn's disease.

Inflammatory bowel diseases - 1 Oct 2013

Strisciuglio Caterina, Miele Erasmo, Wildenberg Manon E, Giugliano Francesca P, Andreozzi Marialuisa, Vitale Alessandra, Capasso Francesca, Camarca Alessandra, Barone Maria V, Staiano Annamaria, Troncone Riccardo, Gianfrani Carmela

Abstract excerpt

BACKGROUND: The single-nucleotide polymorphism T300A of ATG16L1, a Crohn's disease (CD)-associated gene, is responsible for decreased autophagy. This study aimed to investigate the effects of this single-nucleotide polymorphism on the uptake and processing of antigens by dendritic cells (DCs) and the interaction between DC and intestinal epithelium in pediatric patients with CD. METHODS: Pediatric patients who...

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PMID: 24022642
DOI: 10.1097/MIB.0b013e3182a6a11c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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