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Article

Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions.

Journal of Crohn's & colitis - 1 Aug 2013

Strisciuglio Caterina, Duijvestein Marjolijn, Verhaar Auke P, Vos Anne Christine W, van den Brink Gijs R, Hommes Daniel W, Wildenberg Manon E

Abstract excerpt

BACKGROUND AND AIMS: Dendritic cells (DC) are key players in intestinal immunity, as these cells can direct the immune response to either a tolerogenic or an immunogenic phenotype. In the intestine, DC sample and process luminal antigens by protruding dendrites through the epithelial cell layer. At the same time barrier integrity is maintained through the continuous formation of tight junctions. Aberrations in...

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Source

Identifiers

PMID: 22981596
DOI: 10.1016/j.crohns.2012.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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