Article
A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death.
Molecular biology of the cell - 1 Jan 2014
Salinas Raul E, Ogohara Cassandra, Thomas Monica I, Shukla Kajal P, Miller Samuel I, Ko Dennis C
Abstract excerpt
Pyroptosis is proinflammatory cell death that occurs in response to certain microbes. Activation of the protease caspase-1 by molecular platforms called inflammasomes is required for pyroptosis. We performed a cellular genome-wide association study (GWAS) using Salmonella typhimurium infection of human lymphoblastoid cell lines as a means of dissecting the genetic architecture of susceptibility to pyroptosis and...
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