Article
An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the Rectum.
Diseases of the colon and rectum - 1 Jun 2021
Reynolds Ian S, O'Connell Emer, Fichtner Michael, Blümel Anna, Mason Sam E, Kinross James, McNamara Deborah A, Kay Elaine W, O'Connor Darran P, Das Sudipto, Burke John P, Prehn Jochen H M
Abstract excerpt
BACKGROUND: Mucinous adenocarcinoma of the rectum accounts for 10% of all rectal cancers and has an impaired response to neoadjuvant chemoradiotherapy and worse overall survival. To date, insufficient genomic research has been performed on this histological subtype. OBJECTIVE: This study aims to define the mismatch repair deficiency rate and the driver mutations underpinning mucinous adenocarcinoma of the rectum...
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