Article
Consequences of testing for mismatch repair deficiency of colorectal cancer in clinical practice.
Scandinavian journal of gastroenterology - 1 May 2018
Leicher L W, Lammertink M H A, Offerman S R, Morreau H, de Jong M M, de Groot J W B, van Westreenen H L, Vasen H F A, de Vos Tot Nederveen Cappel W H
Abstract excerpt
INTRODUCTION: Mismatch repair deficiency (dMMR) can be found in Lynch syndrome (LS)-associated colorectal carcinoma and in 15% of sporadic colorectal cancer (CRC). Outcome of MMR-deficiency testing is important for surgical decisions as extended colectomy is recommended in young LS-patients with CRC. Moreover, the finding of a dMMR tumour has consequences for the choices of adjuvant chemotherapy as MMR-deficient...
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