The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.

doi:10.1124/jpet.116.235150

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Article

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.

The Journal of pharmacology and experimental therapeutics - 1 Oct 2016

Hampton Caryn, Zhou Xiaoyan, Priest Birgit T, Pai Lee-Yuh, Felix John P, Thomas-Fowlkes Brande, Liu Jessica, Kohler Martin, Xiao Jianying, Corona Aaron, Price Olga, Gill Charles, Shah Kashmira, Rasa Cordelia, Tong Vince, Owens Karen, Ormes James, Tang Haifeng, Roy Sophie, Sullivan Kathleen A, Metzger Joseph M, Alonso-Galicia Magdalena, Kaczorowski Gregory J, Pasternak Alexander, Garcia Maria L

Abstract excerpt

The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target for the development of new mechanism of action diuretics. This idea is supported by the phenotype of antenatal Bartter's syndrome type II associated with...

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PMID: 27432892
DOI: 10.1124/jpet.116.235150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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