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Article

A comparison of the natriuretic and kaliuretic effects of cicletanine and hydrochlorothiazide in prehypertensive and hypertensive humans.

Journal of hypertension - 1 Apr 2012

Wagner Frank, Malice Marie-Pierre, Wiegert Erol, McGrath Helen E, Gildea John, Mitta Shabri, Van Dyck Kristien, De Lepeleire Inge, Johnson-Levonas Amy O, Sisk Christine McCrary, Fernandez Rose, Greenwalt Danielle M, Beals Chan, Carey Robert M, Nunes Irene

Abstract excerpt

OBJECTIVES: The aim of this study was to compare the single-dose effects of thiazide-type diuretics cicletanine and hydrochlorothiazide (HCTZ), on natriuresis and kaliuresis in prehypertensive and treatment-naïve, stage 1 hypertensive patients and to explore the impact of GRK4 gene polymorphisms on thiazide-induced urinary electrolyte excretion. METHODS: The study was a randomized, double-blind,...

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Source

Identifiers

PMID: 22278145
DOI: 10.1097/HJH.0b013e32835022a8

Genes

GRK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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