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Article

Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis.

Immunogenetics - 1 Jan 2013

Geldhoff Madelijn, Mook-Kanamori Barry B, Brouwer Matthijs C, Valls Seron Mercedes, Baas Frank, van der Ende Arie, van de Beek Diederik

Abstract excerpt

Bacterial meningitis is a severe and deadly disease, most commonly caused by Streptococcus pneumoniae. Disease outcome has been related to severity of the inflammatory response in the subarachnoid space. Inflammasomes are intracellular signaling complexes contributing to this inflammatory response. The role of genetic variation in inflammasome genes in bacterial meningitis is largely unknown. In a prospective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23053059
DOI: 10.1007/s00251-012-0653-x

Genes

CARD8
NLRP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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