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Article

TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction.

Neuron - 12 Apr 2012

Penney Jay, Tsurudome Kazuya, Liao Edward H, Elazzouzi Fatima, Livingstone Mark, Gonzalez Miranda, Sonenberg Nahum, Haghighi A Pejmun

Abstract excerpt

Homeostatic mechanisms operate to stabilize synaptic function; however, we know little about how they are regulated. Exploiting Drosophila genetics, we have uncovered a critical role for the target of rapamycin (TOR) in the regulation of synaptic homeostasis at the Drosophila larval neuromuscular junction. Loss of postsynaptic TOR disrupts a retrograde compensatory enhancement in neurotransmitter release that is...

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Source

Identifiers

PMID: 22500638
DOI: 10.1016/j.neuron.2012.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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