Article
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Oct 2025
Takase Masato, Hirata Takumi, Nakaya Naoki, Kogure Mana, Hatanaka Rieko, Nakaya Kumi, Chiba Ippei, Tokioka Sayuri, Nochioka Kotaro, Nakamura Tomohiro, Tsuchiya Naho, Metoki Hirohito, Satoh Michihiro, Narita Akira, Obara Taku, Ishikuro Mami, Ohseto Hisashi, Takahashi Ippei, Kobayashi Tomoko, Kodama Eiichi N, Hamanaka Yohei, Orui Masatsugu, Ogishima Soichi, Nagaie Satoshi, Fuse Nobuo, Sugawara Junichi, Kuriyama Shinichi, Tamiya Gen, Hozawa Atsushi, Yamamoto Masayuki
Abstract excerpt
Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study....
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