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Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening

1 Jan 2013

Abstract excerpt

In many somatic human tissues, telomeres shorten progressively because of the DNA-end replication problem. Consequently, cells cease to proliferate and are maintained in a metabolically viable state called replicative senescence. These cells are characterized by an activation of DNA damage checkpoints stemming from eroded telomeres, which are bypassed in many cancer cells. Hence, replicative senescence has been...

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PMID: 23638436
DOI: 10.3389/fonc.2013.00101

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