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Article

Evidence that the C-terminal domain (CtD) autoinhibits neural repression by Drosophila E(spl)M8.

Genesis (New York, N.Y. : 2000) - 1 Jan 2010

Kahali Bhaskar, Kim Jee-Eun, Karandikar Umesh, Bishop Clifton P, Bidwai Ashok P

Abstract excerpt

Analysis of the retinal defects of a CK2 phosphomimetic variant of E(spl)M8 (M8S(159)D) and the truncated protein M8* encoded by the E(spl)D allele, suggest that the nonphosphorylated CtD "autoinhibits" repression. We have investigated this model by testing for inhibition (in "trans") by the CtD fragment in its nonphosphorylated (M8-CtD) and phosphomimetic (M8SD-CtD) states. In N(+) flies, ectopic M8-CtD...

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PMID: 20014344
DOI: 10.1002/dvg.20581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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