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Article

Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8.

Mechanisms of development - 1 Mar 2004

Karandikar Umesh C, Trott Regina L, Yin Jerry, Bishop Clifton P, Bidwai Ashok P

Abstract excerpt

The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' phosphorylated protein (M8SD). We find that phosphorylation of M8 does not appear to be critical...

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Identifiers

PMID: 15003630
DOI: 10.1016/j.mod.2004.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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