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Article

The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.

Developmental biology - 15 Jan 2012

Yang Yang, Primrose David A, Leung Albert C, Fitzsimmons Ross B, McDermand Matt C, Missellbrook Alison, Haskins Julie, Smylie AnneLiese S, Hughes Sarah C

Abstract excerpt

The signalling activities of Merlin and Moesin, two closely related members of the protein 4.1 Ezrin/Radixin/Moesin family, are regulated by conformational changes. These changes are regulated in turn by phosphorylation. The same sterile 20 kinase-Slik co-regulates Merlin or Moesin activity whereby phosphorylation inactivates Merlin, but activates Moesin. Thus, the corresponding coordinate activation of Merlin...

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PMID: 22133918
DOI: 10.1016/j.ydbio.2011.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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