Article

ERK inhibits Cic repressor function via multisite phosphorylation

2024-05-14

Abstract excerpt

The receptor tyrosine kinase (RTK)/Extracellular Signal-Regulated Kinase (ERK) signaling pathway controls cell proliferation, differentiation, and survival. How ERK activation is relayed to its phosphorylation targets is not well understood. The transcriptional repressor Capicua (Cic) has emerged as a key target for ERK-mediated downregulation in Drosophila and mammals, and mutations in human CIC result in cance...

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Literature Corpus work: 18887a8e-b1a6-5683-b75e-da52a39601e1
DOI: 10.1101/2024.05.14.594119

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