Article
Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila.
Developmental biology - 1 Jan 1999
Lesokhin A M, Yu S Y, Katz J, Baker N E
Abstract excerpt
Dominant Ellipse mutant alleles of the Drosophila EGF receptor homologue (DER) dramatically suppress ommatidium development in the eye and induce ectopic vein development in the wing. Their phenotype suggests a possible role for DER in specifying the founder R8 photoreceptor cells for each ommati...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Cell Line
- Crosses, Genetic
- Drosophila Proteins
- Drosophila melanogaster
- Embryonic Induction
- ErbB Receptors
- Eye
- Female
- Gene Expression Regulation, Developmental
- Humans
- Male
- Molecular Sequence Data
- Morphogenesis
- Mutagenesis, Site-Directed
- Mutation