Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling.

PloS one - 1 Jan 2014

Bose Anasua, Majot Adam T, Bidwai Ashok P

Abstract excerpt

Drosophila Enhancer of split M8, an effector of Notch signaling, is regulated by protein kinase CK2. The phosphatase PP2A is thought to play an opposing (inhibitory) role, but the identity of the regulatory subunit was unknown. The studies described here reveal a role for the PP2A regulatory subunit widerborst (wdb) in three developmental contexts; the bristle, wing and the R8 photoreceptors of the eye. wdb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins
Share to Eye

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Phosphatase 2

Share to Receptors, Notch

Share to Repressor Proteins

Share to Signal Transduction

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 25006677
DOI: 10.1371/journal.pone.0101884
PMCID: PMC4090204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling.PMID 25006677Read ↗

Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8.Semantic proximity Read ↗

The Conserved MAPK Site in E(spl)-M8, an Effector of Drosophila Notch Signaling, Controls Repressor Activity during Eye Development.Semantic proximity Read ↗

Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.Semantic proximity Read ↗

Evidence that the C-terminal domain (CtD) autoinhibits neural repression by Drosophila E(spl)M8.Semantic proximity Read ↗

The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.Semantic proximity Read ↗

The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER.Semantic proximity Read ↗

Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster.Semantic proximity Read ↗

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformationSemantic proximity Read ↗

New insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitment.Semantic proximity Read ↗

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.Semantic proximity Read ↗

Alternative cell fate choice induced by low-level expression of a regulator of protein phosphatase 2A in the Drosophila peripheral nervous system.Semantic proximity Read ↗

Roles of myosin phosphatase during Drosophila development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.