Article
The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.
Biochemical pharmacology - 15 Nov 2016
Sealover Natalie R, Felts Bruce, Kuntz Charles P, Jarrard Rachel E, Hockerman Gregory H, Lamb Patrick W, Barker Eric L, Henry L Keith
Abstract excerpt
The substituted amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy), is a widely used drug of abuse that induces non-exocytotic release of serotonin, dopamine, and norepinephrine through their cognate transporters as well as blocking the reuptake of neurotransmitter by the same transporters. The resulting dramatic increase in volume transmission and signal duration of neurotransmitters leads to...
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