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Article

Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors.

Molecular psychiatry - 1 Jun 2012

Wong M-L, Dong C, Andreev V, Arcos-Burgos M, Licinio J

Abstract excerpt

Major depressive disorder (MDD) is the most common psychiatric disorder and the second overall cause of disability. Even though a significant amount of the variance in the MDD phenotype is explained by inheritance, specific genetic variants conferring susceptibility to MDD explain only a minimal proportion of MDD causality. Moreover, genome-wide association studies have only identified two small-sized effect loci...

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Identifiers

PMID: 22449891
DOI: 10.1038/mp.2012.13
PMCID: PMC3359641

Genes

BDNF
GHRHR
PDLIM5
PSMD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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