Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy.

Pharmacogenetics and genomics - 1 Aug 2017

Tuteja Sony, Wang Lu, Dunbar Richard L, Chen Jinbo, DerOhannessian Stephanie, Marcovina Santica M, Elam Marshall, Lader Ellis, Rader Daniel J

Abstract excerpt

OBJECTIVE: Niacin has been used for seven decades to modulate plasma lipids, but its mechanism of action is still unclear. We sought to determine whether variants in the niacin receptor gene, hydroxyl-carboxylic receptor 2 (HCAR2), are associated with lipid response to treatment. PARTICIPANTS AND METHODS: Coding variants, rs7314976 (p.R311C) and rs2454727 (p.M317I), were genotyped in 2067 participants from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL
Share to Cholesterol, LDL
Share to Delayed-Action Preparations
Share to Hypolipidemic Agents
Share to Lipoprotein(a)
Share to Niacin
Share to Receptors, G-Protein-Coupled
Share to Receptors, Nicotinic

Source

Open in PubMed Open full text

Identifiers

PMID: 28628560
DOI: 10.1097/FPC.0000000000000289
PMCID: PMC5548439

Genes

HCAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy.PMID 28628560Read ↗

Fibrate pharmacogenomics: expanding past the genome.Semantic proximity Read ↗

Effects of phenotypic and genotypic factors on the lipid responses to niacin in Chinese patients with dyslipidemia.Semantic proximity Read ↗

Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network analysis.Semantic proximity Read ↗

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?Semantic proximity Read ↗

Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.Semantic proximity Read ↗

Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures.Semantic proximity Read ↗

Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study.Semantic proximity Read ↗

Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.Semantic proximity Read ↗

Pharmacogenetic study of statin therapy and cholesterol reduction.Semantic proximity Read ↗

Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study.Semantic proximity Read ↗

Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.Semantic proximity Read ↗

An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.