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Article

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

EMBO reports - 1 Sept 2016

Stoica Radu, Paillusson Sébastien, Gomez-Suaga Patricia, Mitchell Jacqueline C, Lau Dawn Hw, Gray Emma H, Sancho Rosa M, Vizcay-Barrena Gema, De Vos Kurt J, Shaw Christopher E, Hanger Diane P, Noble Wendy, Miller Christopher Cj

Abstract excerpt

Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not properly understood. However, many of the functions disrupted in ALS/FTD are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling is facilitated by close physical associations between the two...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Glycogen Synthase Kinase 3 beta

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Share to RNA-Binding Protein FUS

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Source

Open in PubMed Open full text

Identifiers

PMID: 27418313
DOI: 10.15252/embr.201541726
PMCID: PMC5007559

Genes

FUS
VAPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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