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Article

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production.

Acta neuropathologica - 1 Jul 2017

Paillusson Sébastien, Gomez-Suaga Patricia, Stoica Radu, Little Daniel, Gissen Paul, Devine Michael J, Noble Wendy, Hanger Diane P, Miller Christopher C J

Abstract excerpt

α-Synuclein is strongly linked to Parkinson's disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson's disease are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling involves close physical associations between the two organelles that are mediated by binding of the integral ER protein...

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Identifiers

PMID: 28337542
DOI: 10.1007/s00401-017-1704-z
PMCID: PMC5486644

Genes

VAPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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