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Article

The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS

1 Apr 2021

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors. Despite this heterogeneity, a key pathological signature is the mislocalization and aggregation of specific proteins in the cytoplasm, suggesting that convergent pathogenic mechanisms focusing on disturbances in proteostasis are important in ALS. In addition,...

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PMID: 33867942
DOI: 10.3389/fncel.2021.653688

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