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Article

Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons.

Stem cell reports - 13 Feb 2024

Shum Carole, Hedges Erin C, Allison Joseph, Lee Youn-Bok, Arias Natalia, Cocks Graham, Chandran Siddharthan, Ruepp Marc-David, Shaw Christopher E, Nishimura Agnes L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder characterized by progressive muscular weakness due to the selective loss of motor neurons. Mutations in the gene Fused in Sarcoma (FUS) were identified as one cause of ALS. Here, we report that mutations in FUS lead to upregulation of synaptic proteins, increasing synaptic activity and abnormal release of vesicles at the...

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Identifiers

PMID: 38242131
DOI: 10.1016/j.stemcr.2023.12.007
PMCID: PMC10874860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons.PMID 38242131Read ↗

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