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Article

Hijacking of the pleiotropic cytokine interferon-γ by the type III secretion system of Yersinia pestis.

PloS one - 13 Dec 2010

Gendrin Claire, Sarrazin Stéphane, Bonnaffé David, Jault Jean-Michel, Lortat-Jacob Hugues, Dessen Andréa

Abstract excerpt

Yersinia pestis, the causative agent of bubonic plague, employs its type III secretion system to inject toxins into target cells, a crucial step in infection establishment. LcrV is an essential component of the T3SS of Yersinia spp, and is able to associate at the tip of the secretion needle and take part in the translocation of anti-host effector proteins into the eukaryotic cell cytoplasm. Upon cell contact,...

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Identifiers

PMID: 21179438
DOI: 10.1371/journal.pone.0015242
PMCID: PMC3001473

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Source receipt: pubmed, retrieved 7 Sept 2026.

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