Article

WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

2022-04-15

Abstract excerpt

WNT signaling presents an attractive target for cancer therapy due to its widespread oncogenic role. However, the molecular players involved in WNT signaling and the impact of their perturbation remain unknown for numerous recalcitrant cancers including small-cell lung cancer (SCLC). Here we show that beta-catenin, a master mediator of canonical WNT signaling, is not required for SCLC development in genetically en...

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Literature Corpus work: fb4978ba-4cc8-5495-b2de-a1b2995aae6f
DOI: 10.1101/2022.04.14.488408

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