Article
A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis.
Genesis (New York, N.Y. : 2000) - 1 Feb 2009
Yamamoto Masakazu, Shook Nicole A, Kanisicak Onur, Yamamoto Shoko, Wosczyna Michael N, Camp James R, Goldhamer David J
Abstract excerpt
The Cre/lox and FLP/FRT recombination systems have been used extensively for both conditional knockout and cell lineage analysis in mice. Here we report a new multifunctional Cre/FLP dual reporter allele (R26(NZG)) that exhibits strong and apparently ubiquitous marker expression in embryos and adults. The reporter construct, which is driven by the CAG promoter, was knocked into the ROSA26 locus providing an open...
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