Article
Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure (London, England : 1993) - 2 Aug 2016
Broughton Sophie E, Hercus Timothy R, Nero Tracy L, Dottore Mara, McClure Barbara J, Dhagat Urmi, Taing Houng, Gorman Michael A, King-Scott Jack, Lopez Angel F, Parker Michael W
Abstract excerpt
The GM-CSF, IL-3, and IL-5 receptors constitute the βc family, playing important roles in inflammation, autoimmunity, and cancer. Typical of heterodimeric type I cytokine receptors, signaling requires recruitment of the shared subunit to the initial cytokine:α subunit binary complex through an affinity conversion mechanism. This critical process is poorly understood due to the paucity of crystal structures of...
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