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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

13 May 2009

Abstract excerpt

Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha-chain, the first member of the GM-CSF/interleukin (IL)-3/IL-5 family of hemopoietic cytokine receptors to be molecularly characterized. The intervening 2 decades have uncovered a plethora of biologic functions transduced by the GM-CSF receptor (pleiotropy) and revealed distinct signaling...

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PMID: 19436055
DOI: 10.1182/blood-2008-12-164004

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