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Article

Expression of heavy chain‐only antibodies can support B‐cell development in light chain knockout chickens

9 Jul 2016

Abstract excerpt

Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generation of VJCL knockout chickens. In contrast to immunoglobulin heavy chain knockout chickens, which...

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PMID: 27392810
DOI: 10.1002/eji.201546171

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