Article
Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013
Schusser Benjamin, Collarini Ellen J, Yi Henry, Izquierdo Shelley Mettler, Fesler Jeffrey, Pedersen Darlene, Klasing Kirk C, Kaspers Bernd, Harriman William D, van de Lavoir Marie-Cecile, Etches Robert J, Leighton Philip A
Abstract excerpt
Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their functions. Although gene targeting has been used extensively to modify the genomes of mammals, fish, and amphibians, a targeting technology has not been available for the avian genome. Many of the principles of humoral immunity were discovered in chickens, yet the...
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