Article
Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe-Based Single-Nucleotide Polymorphism Array.
The Journal of molecular diagnostics : JMD - 1 Sept 2016
Singh Rajesh R, Mehrotra Meenakshi, Chen Hui, Almohammedsalim Alaa A, Sahin Ayesagul, Bosamra Alex, Patel Keyur P, Routbort Mark J, Lu Xinyan, Ronald Abraham, Mishra Bal Mukund, Virani Shumaila, Medeiros L Jeffrey, Luthra Rajyalakshmi
Abstract excerpt
Gene copy number aberrations (CNAs) represent a major class of cancer-related genomic alterations that drive solid tumors. Comprehensive and sensitive detection of CNAs is challenging because of often low quality and quantity of DNA isolated from the formalin-fixed, paraffin-embedded (FFPE) solid tumor samples. Here, in a clinical molecular diagnostic laboratory, we tested the utility and validated a molecular...
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