Article
Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.
BMC cancer - 7 Apr 2020
Steeghs Elisabeth M P, Kroeze Leonie I, Tops Bastiaan B J, van Kempen Leon C, Ter Elst Arja, Kastner-van Raaij Annemiek W M, Hendriks-Cornelissen Sandra J B, Hermsen Mandy J W, Jansen Erik A M, Nederlof Petra M, Schuuring Ed, Ligtenberg Marjolijn J L, Eijkelenboom Astrid
Abstract excerpt
BACKGROUND: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for testing, genetic markers are rapidly expanding. Simultaneous detection of predictive markers, including mutations, gene amplifications and MSI, will save valuable material, time and costs. METHODS: Using a single-molecule molecular inversion probe...
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